Use of Differin (Adapalene)

It is very important that you use Differin (Adapalene) only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply Differin (Adapalene) to windburned or sunburned skin or on open wounds.

Do not use Differin (Adapalene) in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using Differin (Adapalene) for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using Differin (Adapalene) too soon, your acne may return or get worse.

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Dose of Differin (Adapalene)

Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Differin (Adapalene). If your dose is different, do not change it unless your doctor tells you to do so.

For topical dosage form (gel):
For acne:
Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well.
Children—Use and dose must be determined by your doctor.

Missed Dose of Differin (Adapalene)

If you miss a dose of Differin (Adapalene) , apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage of Differin (Adapalene)

Keep out of the reach of children.
Store away from heat and direct light.
Do not keep outdated Differin (Adapalene) or Differin (Adapalene) that is longer needed.
Be sure that any discarded medicine is out of the reach of children.

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Precautions While Using Differin (Adapalene)

During the first 3 weeks you are using Differin (Adapalene), your acne may seem to get worse before it gets better. Full improvement should be seen within 12 weeks, especially if you use the medicine every day. You should not stop using Differin (Adapalene) if your acne seems worse at first, unless irritation or other symptoms become severe. Check with your doctor if your acne does not improve within 8 to 12 weeks.

Do not apply any topical product to the same area where you are using Differin (Adapalene), unless otherwise directed by your doctor. If applied to the same area treated with Differin (Adapalene), the following products may cause mild to severe irritation of the skin:

Hair products that irritate the skin, such as permanents or hair removal products
Skin products for acne (such as clindamycin or erythromycin) or other skin products containing a peeling agent (such as benzoyl peroxide, resorcinol, salicylic acid, or sulfur)
Skin products that cause one to be more sensitive to the sun, such as those containing spices or lime
Skin products that are too drying or that contain a large amount of alcohol, such as astringents, cosmetics, shaving creams, or after-shave lotions
Skin products that are abrasive, such as some soaps or skin cleansers
Your doctor may ask you to use other topical products, such as benzoyl peroxide, clindamycin, or erythromycin, during your treatment with Differin (Adapalene). Applying the products at different times of the day will lessen the chance of causing skin irritation.

If your skin becomes too dry or red at any time, discuss with your doctor whether you should continue using Differin (Adapalene). Applying creams, lotions, or moisturizers as needed helps lessen these skin problems.

During treatment with Differin (Adapalene), avoid getting too much sun on treated areas and do not use sunlamps. Since your skin may be more prone to sunburn or skin irritation, use sunscreen or sunblocking lotions regularly with a sun protection factor (SPF) of 15 or more. Wear protective clothing against sun, wind, and cold weather.

Side Effects of Differin (Adapalene)

Along with its needed effects, Differin (Adapalene) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur, they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common--especially during the first month of use
Burning sensation or stinging of skin; dryness and peeling of skin; itching of skin; redness of skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if the following side effect continues or is bothersome:

Rare--more common during the first month of use

Worsening of acne
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.